New Directions of Maternal Factors and Ultrasound Markers in the Prediction of Early and Late Pre-Eclampsia

Abstract

Pre-eclampsia (PE) is one of the hypertensive pregnancy disorders, de novo protein-uric hypertension that develops after 20 weeks of gestation and it is a systemic disorder associated with high maternal and neonatal morbidity and mortality. The aim of this study was to determine the usefulness as a screening method for early? and late?onset pre?eclampsia of a combination of a series of measurements, including maternal characteristics and UtA Doppler measured at 11?+?0 to 13?+?6?weeks of gestation and 22 to 24 weeks of gestation. This is a retrospective cohort study, during January - December 2017, of women who have had Pre-eclampsia at a tertiary referral University Hospital of Obstetrics and Gynecology Koço Gliozheni in Tirana, Albania. In total were 62 women with Pre-eclampsia during this period of time. Maternal and neonatal data were collected from the case notes and was done uterine artery color Doppler examination at 22-24 weeks of gestation. The ultrasound machine used was Aloka Echo Camera L. All data were calculated with SPSS 15.0. T-test, Chi-Square test, Fisher test and Correlation were used for statistical analysis. In total, 62 women with Pre-eclampsia were classified: 32 percent Early PE and 68 percent Late PE. In Doppler examination 26 percent had bilateral notch at uterine artery, 12 percent notch at AU Dexter, 15 percent notch at AU Sinister and 47,1 percent without notch. 58.8 percent Apgar score in the first minute was 8 and 67.6 percent in the fifth minute was 9. Mean Fetus Weight at Early PE 1543.18 g and at Late PE 2623.91 g and mean NICU was 37.82 days at early PE and 6.87 days at Late PE. There is a very significant correlation between Fetus Weight (g) and NICU (R=-0.84, p smaller than 0.001) also there is a significant difference between the presence of IUGR on early and Late PE (Fishers Exact Test = 8.192, p=0.008). There is a significant difference on CPR values on early and late PE (T-test = -2.127, p=0.041).