Autism is not a Disease of Definitive Cure but it is a Typical Disease of Definite Prevention

Abstract

Aim: Demonstration of a possible role of Helicobacter pylori in the etio-pathology of autism that makes prevention of the disease possible. Background: H. pylori was suggested as a reason related to many medical challenges. H. pylori when forced to migrate to the colon due to the antibiotic violence; the accumulated H. pylori-produced colonic ammonia in profuse amounts conforms with the elevated serum ammonia among autistic children and its toxic effect with the hypothesis of the entire brain compromise suggested in autism. Interestingly, kids develop H. pylori trans-familial during the time of weaning which is the typical timing of developing autistic features. Ammonia is the producer of nitric oxide in the gut via a shear stress effect while nitric oxide is a cure and a poison at the mean time; that is in normal residual levels it is healthy while in excess amounts it is toxic. This could explain the early brilliant behaviors in some autistic kids which are followed by loss of skills later. A striking observation has been emphasized by some study where all parents of the autistic kids of that study were having frank H. pylori dyspepsia, the kids were also positive for H. pylori fecal antigen and some kids were recovered from prodromal symptoms via early colon clear from the colonic H. pylori strains. Conclusion: Autism then, when established, is not a disease of definitive cure but it could be a typical disease of definite prevention via protection from transmission of parents H. pylori strains to kids.